TP53mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer
نویسندگان
چکیده
منابع مشابه
TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer
To determine early somatic changes in high-grade serous ovarian cancer (HGSOC), we performed whole genome sequencing on a rare collection of 16 low stage HGSOCs. The majority showed extensive structural alterations (one had an ultramutated profile), exhibited high levels of p53 immunoreactivity, and harboured a TP53 mutation, deletion or inactivation. BRCA1 and BRCA2 mutations were observed in ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2015
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkv111